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I Penicillin G, Penicillin V
II Methacilin, Nafcilin (Beta-Lactamase resistant)
III Amoxicillin, Ampicillin
IV anti-pseudomonal
• Methacilin resistant: alteration of the a.a. sequences of PBP
• Renal excretion mainly by secretion (inhibited by probenecid)
• Side effects: hypersensitivity due to minor determinants
• Methacilin: interstitial nephritis
USES:
• Gram +ve infections
• Treponema (Syphilis DOC)
• Pseudomonas (Penicillin IV + Aminoglycosides)
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