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The numbers of people reported with syphilis in the U.S. decreased dramatically between the mid-
1940s and 2000 (falling from almost 100,000 yearly cases of primary and secondary syphilis to less
than 6,000);1 numbers of reported cases have risen slightly since then. People in correctional
institutions, people living in southern states, men and African Americans are disproportionately (most)
affected.1, 2
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