CONTENTS
Preface -------------------------------------------------------------------------------------------------------------------------------------------------------v
Methodology ---------------------------------------------------------------------------------------------------------------------------------------------vi
Acknowledgements --------------------------------------------------------------------------------------------------------------------------------vii
Abbreviations --------------------------------------------------------------------------------------------------------------------------------------------ix
Chapter 1 Epidemiology, burden of disease and transmission
1.1 Dengue epidemiology -----------------------------------------------------------------------------------------------3
1.2 Burden of disease --------------------------------------------------------------------------------------------------------12
1.3 Dengue in international travel --------------------------------------------------------------------------------13
1.4 Transmission ---------------------------------------------------------------------------------------------------------------------14
1.5 References ------------------------------------------------------------------------------------------------------------------------17
Chapter 2 Clinical management and delivery of clinical services
2.1 Overview --------------------------------------------------------------------------------------------------------------------------25
2.2 Delivery of clinical services and case management ---------------------------------29
2.3 Recommendations for treatment ----------------------------------------------------------------------------32
2.4 References ------------------------------------------------------------------------------------------------------------------------54
Chapter 3 Vector management and delivery of vector control services
3.1 Overview --------------------------------------------------------------------------------------------------------------------------59
3.2 Methods of vector control --------------------------------------------------------------------------------------60
3.3 Delivery of vector control interventions -------------------------------------------------------------72
3.4 References ------------------------------------------------------------------------------------------------------------------------86
Chapter 4 Laboratory diagnosis and diagnostic tests
4.1 Overview --------------------------------------------------------------------------------------------------------------------------91
4.2 Considerations in the choice of diagnostic methods --------------------------------93
4.3 Current dengue diagnostic methods ----------------------------------------------------------------97
4.4 Future test developments -------------------------------------------------------------------------------------------103
4.5 Quality assurance --------------------------------------------------------------------------------------------------------104
4.6 Biosafety issues --------------------------------------------------------------------------------------------------------------104
4.7 Organization of laboratory services ------------------------------------------------------------------104
4.8 References ------------------------------------------------------------------------------------------------------------------------106
Chapter 5 Surveillance, emergency preparedness and response
5.1 Overview --------------------------------------------------------------------------------------------------------------------------111
5.2 Dengue surveillance ----------------------------------------------------------------------------------------------------111
5.3 Dengue preparedness planning and response --------------------------------------------123
5.4 Programme assessment ---------------------------------------------------------------------------------------------128
5.5 References ------------------------------------------------------------------------------------------------------------------------132
Chapter 6 New avenues
6.1 Overview --------------------------------------------------------------------------------------------------------------------------137
6.2 Dengue vaccines ----------------------------------------------------------------------------------------------------------137
6.3 Dengue antiviral drugs ----------------------------------------------------------------------------------------------141
6.4 References ------------------------------------------------------------------------------------------------------------------------144
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